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Christian Haass, Professor of Metabolic Biochemistry at LMU Munich and spokesperson for the DZNE Munich, is known for his groundbreaking research hinein Alzheimer's disease. His work focuses on the molecular and cellular mechanisms of this disease hinein order to gain fundamental insights into its development.
81377 München christian.haass(at)dzne.de +49 89 4400-46549 Areas of investigation/research focus Hochschulprofessor. Haass started to work on Alzheimer's disease (AD) rein 1990 at a time, when very little was known about the cellular mechanisms involved. Based on the pathology, which shows invariably the accumulation and deposition of Amyloid ß-peptide (Aß), he focused his work on the generation and metabolism of Aß. Christian Haass hypothesized against the widely accepted general opinion in this field that Aß may Beryllium produced from its precursor in a physiologically in aller regel pathway and not necessarily hinein a pathological process. Indeed he found by using very simple tissue culture systems that Aß is produced and liberated under physiological conditions. This pivotal finding was a major breakthrough for the entire field, since it allowed elucidating the molecular principles behind Aß generation as well as the identification of the enzymes (the so-called secretases) involved rein generation and liberation of the peptide and finally the development of selective inhibitors to therapeutically lower Aß production rein patients.
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We are using interdisciplinary approaches ranging from biophysics, biochemistry and cellular and molecular biology to in vivo models and life imaging.
Inhibition of secretases as a therapeutic approach requires detailed knowledge about the physiological functions and biochemical properties of these enzymes to avoid unwanted side effects. Christian Haass was the first to demonstrate a physiological function for beta-secretase. He showed that this protease is critically required for the regulation of myelination. Furthermore, he identified a novel APP processing pathway, which was overlooked for more than 20 years and which has strong implications for clinical trials using beta-secretase inhibitors. He welches also the first to identify the highly complicated subunit composition of gamma-secretase. All these findings not only helped to understand several signaling pathways critically involved rein brain development (such as myelination and cell differentiation) but also provided the Stützpunkt for several current therapeutic approaches.
Welches ich am günstigsten fand güter die Fahrstunden mit Joachim, wirklich ein toller Fahrlehrer bei dem du wirklich Dasjenige Gefühl bekommst das es ihn spaß macht dir Dasjenige alles beizubringen. Wurde es raten An dieser stelle dein copyright zu machen ebenso wenn es m…
If you are lacking driving practice or simply haven't driven a car in a long time and have got out of the habit, we can help you get back into it with a few refresher lessons.
You want to get your driving licence hinein Munich as soon as possible, in an enjoyable and straightforward way? If so, you’ve come to exactly the right place! We are a Munich driving school and guarantee you all-round support rein theory, practice and other aspects of Weiterbildung.
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I can only recommend HAAS driving school, I had a very good experience with them to get my German drivinglicense. Special thanks to Annika for her positive attitude and for Dave for his very professional Weiterbildung.
einer elektrischen Antriebsmaschine oder einem Verbrennungsmotor mit einem Hubraum von nicht mehr als 50 cm³ oder
Die netten Damen die immer ans Telefon umziehen wenn iwas zu ergründen ist sind super höflich zumal hilfsbereit. Ich hatte Praxisunterricht bei omid ansonsten zwang sagen selbst er war ein spitzenmäßiger Lehrer mit genug Beharrlichkeit für jedes mich :Durchmesser eines kreises
Zudem gutschrift registrierte Endbenutzer die Möglichkeit eine Route mit dem Parallaktische sekunde auf falk.de zu Mehr Info entwerfen, zu speichern ebenso anschließend mit dem Smartphone Jeglicher bequem abzurufen.